England reached 36 for 2 at close on day three of the second Test chasing 297 to beat Pakistan in Multan.
England lost both openers Zak Crawley for 3 and first innings centurian Ben Duckett without scoring.
Ollie Pope is not out 21 and Joe Root, 12.
Earlier, England bowled out the host for 221 in their second innings. Salman Agha led the way with 63 against Shoaib Bashir 4 for 66 and Jack Leach 3 for 67.
England lead the series 1-0.