The big showdown at the San Siro in Milan featuring Inter Milan against Arsenal, takes the spotlight on another loaded day of European Champions League action on Wednesday.
Arsenal will be without midfielder Declan Rice who picked up a foot injury in training and didn’t travel with the team to Italy.
However, it could also mark the return of captain Martin Odegaard who has been out for two months with an ankle injury.
In other games Reggae Boy Leon Bailey and his Aston Villa team are in Belgium to face Club Brugge, Paris Saint Germain welcomes the visit of Atletico Madrid, Bayern Munich are at home to Benfica and Sparta Prague will face Brest.